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Liver damage and renal dysfunction: 5 case reports In a retrospective study of 15 patients with refractory cryptococcal meningitis, treated between June 2013 and June 2017 in a hospital in China, five patients (2 women and 3 men) aged 46–80 years were described; who developed liver damage or renal dysfunction following treatment with amphotericin-B, fluconazole or flucytosine for cryptococcal meningitis [time to reactions onsets not stated; not all doses and outcomes stated]. The patients, who had cryptococcal meningitis (Cryptococcus neoformans) were admitted to a hospital, and subsequently, underwent the placement of the ommaya reservoirs under periosteum according to the surgical procedure. Prior to the implant placement, one of the 5 patients was treated systemic administration of amphotericin-B, flucytosine [5-flucytosine] and treated fluconazole for 3 months. Following the surgery, all of the 5 patients started receiving intracerebroventricular amphotericin-B injection daily along with dexamethasone. This was followed by CSF aspiration to relieve the elevated intracranial pressure. Subsequently, the patients developed liver damage (2 patients), renal dysfunction (1 patient) or both liver damage and renal dysfunction (2 patients). The patients had received amphotericin-B for 51–94 days. One of the 5 patients died due to multiorgan dysfunction. Wan Y, et al. Clinical characteristic of 15 cases of cryptococcal meningitis treated with Ommaya reservoir. Acta Neurologica Belgica 120: 1139-1145, No. 5, Oct 2020. 803515229 Available from: URL: http://doi.org/10.1007/s13760-019-01193-5

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Reactions 14 Nov 2020 No. 1830