• PDF / 169,938 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 89 Downloads / 150 Views

DOWNLOAD

REPORT

---

1 S

Acute liver failure: case report A 24-year-old man developed acute liver failure during treatment with amphotericin-B for disseminated Talaromyces marneffei infection. The man presented with a 3-month history of intermittent diarrhoea and a recent week of uncontrollable high fever. Then, he was admitted in hospital, China. On admission, he received unspecified antibacterial treatment and supportive care, including replenishing electrolytes, fluid and unspecified human serum albumin. After further investigations, he was diagnosed with disseminated Talaromyces marneffei infection. Subsequently, he started receiving IV amphotericin B 0.6 mg/kg/day along with voriconazole. After, 7 days of treatment with amphotericin B (on hospital day 20), he presented with irritability and developed unconsciousness with gatism 2 hours later. The vital investigations showed the following: body temperature 37 °C, BP 123/71mm Hg, pulse rate 132 beats per minute, respiratory rate 29 breaths per minute and oxygen saturation of 99%. The physical examination showed coma with dilated pupils (0.3cm). Laboratory investigations showed increased levels of blood ammonia, WBCs, lactate dehydrogenase, AST, ALT and prothrombin time. Blood gas analysis showed the following: lactic acid 27 mmol/L, partial pressure of carbon dioxide 9.4mm Hg. He continued to develop acute liver failure with hepatic encephalopathy and prothrombin time prolongation. After one week, he died. Chen D, et al. Unusual disseminated Talaromyces marneffei infection mimicking lymphoma in a non-immunosuppressed patient in East China: a case report and review of the 803518665 literature. [Review]. BMC Infectious Diseases 20: 800, No. 1, 28 Oct 2020. Available from: URL: http://doi.org/10.1186/s12879-020-05526-1

0114-9954/20/1833-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 5 Dec 2020 No. 1833