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Drug-induced hepatic disorder and drug eruption: case report A 9-year-old boy developed drug-induced hepatic disorder and drug eruption during treatment with cefotaxime, meropenem and ampicillin/sulbactam for sinus-related epidural abscess caused by Listeria monocytogenes [not all dosages stated; routes not stated]. The boy was admitted to Kawasaki Municipal Hospital, Japan with fever, swelling and pain around his right eye for the last 5 days. He was eventually diagnosed with right sphenoiditis and epidural abscess in the right middle cranial fossa. A right foramen rotundum osteolysis was also noted. Antibiotic therapy with meropenem 2g daily and cefotaxime 4g daily were thus initiated. On the next day, he underwent endoscopic drainage of the right sphenoidal sinus. On the 7th day of admission, an improvement in his symptoms was noted. Subsequent blood and pus culture were found to be negative possibly due to the effect of antimicrobial therapy. However, the nasopharyngeal culture identified Haemophilus influenzae. On the 10th day of admission, he was found to have developed a brain abscess secondary to Listeria monocytogenes [aetiology not stated]. Ampicillin/sulbactam was therefore initiated. However, he subsequently developed drug-induced hepatic disorder and drug eruption [durations of treatments to reactions onsets not stated]. The boy’s antimicrobial treatment was therefore switched to ampicillin. On the 53rd day of admission, a reduction in the epidural and brain abscess was noted and his ampicillin treatment was switched to amoxicillin. On the next day, he was discharged home. Thereafter, he completed the scheduled 4 weeks of amoxicillin therapy [outcomes not stated]. Tamaoka S, et al. A 9-year-old boy with a sinus-related epidural abscess caused by Listeria monocytogenes. Pediatrics International 62: 502-503, No. 4, Apr 2020. Available 803500620 from: URL: http://doi.org/10.1111/ped.14111

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Reactions 12 Sep 2020 No. 1821