An Emerging Role for Anti-inflammatory Agents for Chemoprevention
There have been a number of promising recent developments in the prevention of colorectal cancer. This book examines in detail important aspects of the current status of and future prospects for chemoprevention of colorectal tumors, particularly using ant
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Andrew T. Chan Elmar Detering •
Editors
Prospects for Chemoprevention of Colorectal Neoplasia Emerging Role of Anti-Inflammatory Drugs
123
Editors Andrew T. Chan Division of Gastroenterology Massachusetts General Hospital Harvard Medical School Boston, MA USA
ISSN 0080-0015 ISBN 978-3-642-30330-2 DOI 10.1007/978-3-642-30331-9
Elmar Detering Global Medical Affairs (Primary Care) Bayer Pharma AG, Berlin Germany
ISBN 978-3-642-30331-9
(eBook)
Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012943957 Ó Springer-Verlag Berlin Heidelberg 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
An Emerging Role for Anti-inflammatory Agents for Chemoprevention. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia . 1 Molecular Basis of Colorectal Adenoma and Carcinoma . . . . . . . . 1.1 Genetic Basis of Adenoma-Carcinoma Sequence. . . . . . . . . . 1.2 Adenomatous Polyposis Coli. . . . . . . . . . . . . . . . . . . . . . . . 1.3 The Microsatellite Instability Pathway in CRC . . . . . .
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