An exploratory investigation of the influence of publication on translational medicine research
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COMMENTARY
An exploratory investigation of the influence of publication on translational medicine research Commentary
Lisa J Douet*, Danielle Preedy, Vaughan Thomas and Ian A Cree
Abstract Background: Changes in clinical practice are brought about by the weight of clinical evidence for and against an intervention. Clinical evidence of efficacy relies on the dissemination of research results, usually by publication in medical journals which is often seen as a pre-requisite for progression of an intervention through further clinical trials or implementation studies. How far has research progressed along the translational pathway?: We undertook an exploratory exercise to determine where basic and translational medical research is currently published. Original research articles (329 in total) published in high impact general and specialist medical journals were classified into different stages of research within the translational medicine pathway. Where is translational research published?: The general medical journals had the broadest spread of published research over the translational pathway. The specialist journals tended to be positioned to disseminate the research findings of early stage translational research from basic science results through to early stages of clinical testing. Conclusion: It is not possible for one journal to satisfy all the needs of the reader and the author along the translational medicine pathway. For an intervention to progress along the translational pathway background information should be readily accessible in the article. This pathway is currently being actively managed by the funding agencies but the next challenge is to ensure the pathway operates efficiently and does not allow promising innovations to languish and to provide a smoother transition for interventions to reach the clinic in a quicker timescale. It is clear that the dissemination of results in the right place at the right time is crucial to the transition of an intervention from the laboratory to clinical practice. Introduction The status of translational research (defined as the progression of scientific advance from inception to clinical practice) has drawn increasing attention as it is seen to be essential to the development of new treatments from advances in biomedical science [1-5]. In 2006, the NIH introduced the Bench to Bedside awards, with the aim of encouraging collaboration between clinicians and basic scientists across institutes. In the same year the Cooksey review [6] was commissioned to undertake an independent review for the public funding of health research in the UK. The report identified two key gaps in the transitional medicine pathway, described as the early phase and the late phase gaps (Figure 1). These gaps limited the * Correspondence: [email protected] 1
NIHR Evaluation, Trials and Studies Coordinating Centre, University of Southampton, SO16 7NS, UK Full list of author information is available at the end of the article
progress of new interventions through the translat
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