An overview of polymeric nano-biocomposites as targeted and controlled-release devices
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REVIEW
An overview of polymeric nano-biocomposites as targeted and controlled-release devices Muhammad Rahim 1
&
Mas Rosemal Hakim Mas Haris 1 & Najm Us Saqib 2
Received: 8 August 2020 / Accepted: 28 August 2020 # International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract In recent years, controlled drug delivery has become an important area of research. Nano-biocomposites can fulfil the necessary requirements of a targeted drug delivery device. This review describes use of polymeric nano-biocomposites in controlled drug delivery devices. Selection of suitable biopolymer and methods of preparation are discussed. Keywords Biopolymers . Controlled drug delivery . Nano-biocomposites . Nano-materials
Introduction Nanotechnology offers new ideas for the development of improved diagnostic and therapeutic tools in surgical and medical treatment (Broichsitter et al. 2010). Nanotechnology is set to play an important role in sustained and targeted drug delivery applications due to its ability to provide tailored active site chemistry and drastically increase the surface area of nanoscale particles (Liu and Webster 2010; Shi et al. 2010). Nanobiocomposites and nanoparticles have already been used for controlled and targeted drug delivery (Steichen et al. 2013; Alba et al. 2019). Polymeric nano-biocomposites (PNBs) are materials derived from the combination of polymer-polymer or nano-scale fillers and polymers whereby the fillers may be organic or inorganic clays, metal nanoparticles and hydroxyapatite (Armentano et al. 2010). Nano-composites constitute a fascinating multidisciplinary area which brings together material science, biological science and nanotechnology and have significant impact in the area of medical science (Liu and Webster 2010). Biodegradable polymers have attracted much attention in recent years due to reasons associated with the environment and minimization of natural fossil resources (Rahim and Mas
* Muhammad Rahim [email protected] 1
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Pulau Penang, Malaysia
2
Department of Zoology, University of Buner, Buner, KP, Pakistan
Haris 2015; Rahim and Mas Haris 2016; Gao et al. 2019; Rahim and Mas Haris 2019). In a similar fashion, researchers have been inspired to produce environment-friendly advance nano-composite materials (Bordes et al. 2009). Biopolymers and clay minerals represent interesting constituents in agricultural and pharmaceutical products (Aguzzi et al. 2010). In recent years, such biopolymers and clay nanobiocomposites have attracted much attention for therapeutic and medical applications (Sasmal et al. 2009). Typical applications of biopolymers in pharmaceutics are prosthesis for tissue replacement, artificial organs and sustained drug and vaccine release devices (Chen et al. 2007a, b; Liu and Webster 2010). Nano-biocomposites can also be used for the treatment of certain tissue and bone diseases (Basha et al. 2015).
Nano-structure biocomposites Nano-s
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