An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity
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RESEARCH ARTICLE
Open Access
An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity Ruoxi Liu1†, Xueling Yuan1†, Jing Yu2, Qi Quan1, Haoye Meng1, Cheng Wang1, Aiyuan Wang1, Quanyi Guo1, Jiang Peng1* and Shibi Lu1*
Abstract Background: Knee osteoarthritis (KOA) is the most prevalent form of knee joint disease and characterized by the progressive degeneration of articular cartilage. Although pathology of KOA remains unknown, genetic factors are considered to be the major cause. Asporin is a group of biologically active components of extracellular matrix (ECM) in articular cartilage, and asporin gene (ASPN) D-repeat polymorphism was reported to be associated with KOA. Thus, our meta-analysis is aimed at investigation of the association between asporin D-repeat polymorphism and susceptibility of KOA. Methods: We gathered data from MEDLINE, Embase, OVID, and ScienceDirect to search relevant published epidemiological studies through April 2017. Compared with previous studies, our meta-analysis is the first study to investigate the association of ASPN D15, D16, and D17 alleles and KOA susceptibility by ethnic- and sex-stratified subgroup analysis. Results: We found no significant association between D15 allele and susceptibility to KOA (OR = 1.05, 95% CI 0.95– 1.17) in overall population. The same results were observed in the analysis of D16 (OR = 1.01, 95% CI 0.80–1.28) and D17 alleles (OR = 1.28, 95% CI 0.91–1.80). The ethnic- and sex-subgroup analyses did not alter the ORs. However, significant association was detected in the sensitivity analysis of D17 in overall population (OR = 1.05, 95% CI 0.95– 1.17) and Asian population (OR = 1.78, 95% CI 1.02–3.11, P < 0.05). Conclusion: Our results indicated that D-repeat polymorphism of ASPN may not play a major role in susceptibility of KOA in ethnic- and sex-specific analysis. Because of the limitations of the present meta-analysis, firm conclusions could not be drawn based on the current evidence, and further studies are required to detect genuine role of ASPN. Keywords: Aspartic acid, Osteoarthritis, Knee, Gender, Ethnicity, Meta-analysis, Polymorphism
Background Osteoarthritis (OA), which is characterized by the progressive degeneration of articular cartilage in joints, is one of the most common joint diseases that mainly affects the knees [1, 2]. Joint stiffness and pain appear to be the first symptoms, and joint swelling followed as the result of effusion and synovitis [3]. The knee osteoarthritis (KOA) has been identified of all ages and * Correspondence: [email protected]; [email protected] † Equal contributors 1 Institute of Orthopedics, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Chinese PLA General Hospital, FuXing Road 28th, Beijing 100853, China Full list of author information is available at the end of the article
considered as the most common cause of disability after middle age [4]. However, current therapeutic method
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