Analysis of Post-Translational Modifications and Proteolysis in Neuroscience

This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of

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Jennifer Elizabeth Grant Hong Li Editors

Analysis of Post-Translational Modifications and Proteolysis in Neuroscience

NEUROMETHODS

Series Editor Wolfgang Walz University of Saskatchewan Saskatoon, SK, Canada

For further volumes: http://www.springer.com/series/7657

Analysis of Post-Translational Modifications and Proteolysis in Neuroscience Edited by

Jennifer Elizabeth Grant Department of Biology University of Wisconsin-Stout Menomonie, Wisconsin, USA

Hong Li Department of Microbiology, Biochemistry and Molecular Genetics Rutgers University—New Jersey Medical School Cancer Center Newark Newark, NJ, USA

Editors Jennifer Elizabeth Grant Department of Biology University of Wisconsin-Stout Menomonie, Wisconsin, USA

Hong Li Department of Microbiology, Biochemistry and Molecular Genetics Rutgers University—New Jersey Medical School Cancer Center Newark Newark, NJ, USA

ISSN 0893-2336 ISSN 1940-6045 (electronic) Neuromethods ISBN 978-1-4939-3470-6 ISBN 978-1-4939-3472-0 (eBook) DOI 10.1007/978-1-4939-3472-0 Library of Congress Control Number: 2016946421 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York

Preface to the Series Experimental life sciences have two basic foundations: concepts and tools. The Neuromethods series focuses on the tools and techniques unique to the investigation of the nervous system and excitable cells. It will not, however, shortchange the concept side of things as care has been taken to integrate these tools within the context of the concepts and questions under investigation. In this way, the series is unique in that it not only collects protocols but also includes theoretical background information and critiques which led to the methods and their development. Thus it gives the reader a better understanding of the origin of the techniques and th