Analysis of three-chamber view conventional and tagged cine MRI in patients with suspected hypertrophic cardiomyopathy
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RESEARCH ARTICLE
Analysis of three‑chamber view conventional and tagged cine MRI in patients with suspected hypertrophic cardiomyopathy Teodora Chitiboi1,2 · Mikael Kanski2 · Lennart Tautz3 · Anja Hennemuth3 · Dan Halpern2 · Mark Sherrid2 · Leon Axel2 Received: 5 June 2019 / Revised: 13 January 2020 / Accepted: 5 February 2020 © European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 2020
Abstract Objectives To investigate the potential value of adding a tagged three-chamber (3Ch) cine to clinical hypertrophic cardiomyopathy (HCM) magnetic resonance imaging (MRI) protocols, including to help distinguish HCM patients with regionally impaired cardiac function. Methods Forty-eight HCM patients, five patients with “septal knuckle” (SK), and 20 healthy volunteers underwent MRI at 1.5T; a tagged 3Ch cine was added to the protocol. Regional strain, myocardial wall thickness, and mitral valve leaflet lengths were measured in the 3Ch view. Results In HCM, we found a reduced tangential strain with decreased diastolic relaxation in both hypertrophied (p = 0.003) and remote segments (p = 0.035). Strain in the basal septum correlated with the length of the coaptation zone + residual leaflet (r = 0.48, p
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