Anaphylaxis and Hypersensitivity Reactions
Despite wide recognition as a serious public health problem, anaphylaxis and hypersensitivity reactions remain under-recognized and under-diagnosed. This book fills the gaps in our understanding of the identification of triggers, recognition of clinical p
- PDF / 6,823,665 Bytes
- 366 Pages / 504 x 720 pts Page_size
- 79 Downloads / 225 Views
wwwwwwwwwwwwwwwww
Mariana C. Castells, MD Editor
Anaphylaxis and Hypersensitivity Reactions
Editor Mariana C. Castells, MD Brigham and Women’s Hospital Harvard Medical School Boston, MA USA [email protected]
ISBN 978-1-60327-950-5 e-ISBN 978-1-60327-951-2 DOI 10.1007/978-1-60327-951-2 Springer New York Dordrecht Heidelberg Londont © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
A 2007 National Electronic Injury Surveillance System (NEISS) indicated that in the USA, 10% of the emergency room visits were due to anaphylaxis. The median age of the patients was 26 years, and 24% of the visits involved children less than 5 years of age who reacted to peanut or tree nuts. Only 19% of the patients received epinephrine and 57% of the patients presenting symptoms compatible with anaphylaxis were not recognized as having anaphylaxis upon discharge. Anaphylaxis is a recognized public health problem with increased prevalence, and yet because of its acute onset and the lack of specific biochemical markers, underrecognized and underdiagnosed. Anaphylaxis is defined as the most severe of the allergic reactions, with a rapid onset and which may cause death if prompt treatment is not installed. It occurs after exposure to an allergen in a previously healthy individual and can involve most organ systems in minutes, including the skin, gastrointestinal, respiratory, and cardiovascular systems. Death can be caused by cardiovascular collapse or laryngeal edema and asphyxiation. Allergens most commonly associated include foods with peanuts and nuts being the most frequent in children, and medications including antibiotics, monoclonals, and chemotherapy drugs such as platins and taxenes. Hymenoptera stings and exercise are wellrecognized treatable causes of anaphylaxis. Mastocytosis and mast cell activation syndromes can present as anaphylaxi
Data Loading...
