Angioedema
Angioedema without weals is a distinct clinical pattern with different etiologies. It may require a management different from that of angioedema with weals. Histaminergic angioedema in chronic urticaria, allergic reactions, and physical urticarias develop
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Urticaria and Angioedema
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Urticaria and Angioedema
Torsten Zuberbier • Clive Grattan • Marcus Maurer
Urticaria and Angioedema
Prof. Dr. med. Torsten Zuberbier Department of Dermatology and Allergy Allergy-centre-Charité Charité-Universitätsmedizin Berlin Charitéplatz 1 10117 Berlin Germany Email: [email protected]
Prof. Dr. med. Marcus Maurer Department of Dermatology and Allergy Allergy-centre-Charité Charité-Universitätsmedizin Berlin Charitéplatz 1 10117 Berlin Germany Email: [email protected]
Clive E. H. Grattan, MA, MD, FRCP Department of Dermatology Norfolk and Norwich University Hospital Norwich NR4 7UY United Kingdom Email: [email protected]
ISBN: 978-3-540-79047-1
e-ISBN: 978-3-540-79048-8
DOI: 10.1007/978-3-540-79048-8 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2009934505 © Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: eStudioCalamar, Figueres/Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Urticaria is one of the most common diseases in dermatology and allergy. Unlike many other diseases, the fleeting nature of the wheals makes first diagnosis by both patients and physicians in many cases easy. However, this only refers to the ordinary wheals. The disease itself is highly complex in nature, with variety of clinical manifestations ranging from pinpointsized wheals to extensive angiodema. Complexity is also seen in the diversity of possible eliciting factors, the many different clinical subtypes and the therapeutic responsiveness. Only in recent years has a better understanding of the diversity in the different subtypes led to new classifications and new evidence-based guidelines for diagnostics and management of the disease. While mast cells are in the center of most urticaria reactions, it is now clearly understood that the responsible mediators are not only limited to histamines. The cur
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