Animal Models
The roles of human filaggrin in health and disease have been modeled with experimental animal models, mostly mice. Mouse models have provided important information relevant to the roles of filaggrin, but it must always be considered that mice are not huma
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Animal Models Kozo Nakai, Kozo Yoneda, and Yasuo Kubota
Contents 7.1
Introduction ..............................................
65
7.2
The Discovery of Filaggrin in Animal Models (Mouse and Rat)........
66
Filaggrin Gene-Mutated Mouse and Filaggrin-Null Mouse ....................... Flaky Tail Mouse ....................................... Filaggrin-Null Mouse ................................
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7.3 7.3.1 7.3.2 7.4 7.4.1 7.4.2 7.4.3 7.4.4 7.4.5
7.4.6 7.4.7 7.4.8 7.4.9 7.4.10 7.4.11
Mutant Mice with Abnormal Filaggrin Expression................................................. Epilation Mutant Mouse ............................ Pupoid Fetus Mutant Mouse ...................... SENCAR Mouse ........................................ Flaky Skin Mouse ...................................... Epidermal-Specific Glycosylphosphatidylinositol -Anchor-Deficient Mouse .......................... Mouse Lacking the C-Terminal Region of Connexin43............................................ Peroxisome-Proliferator-Activated Receptor-γ-Deficient Mouse ...................... 25ohd 1α-Hydroxylase Knockout Mouse .. Spermidine/Spermine N1-Acetyltransferase Transgenic Mouse.... Nude Mouse ............................................... Spink5 (R820X/R820X) Mouse ................
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7.4.12 7.4.13 7.4.14 7.4.15 7.4.16 7.4.17 7.4.18 7.4.19
CAP1/Prss8-Deficient Skin Mouse............ Heterozygous Inv-Cldn6 Mouse ................ DHCR24−/− Mouse ................................... Arnt-Null Skin Mouse ............................... 12R-LOX-Deficient Mouse ....................... Caspase-14-Deficient Mouse ..................... PPARβ/δ Knockout Mouse ........................ Glucocorticoid Receptor Knockout Mouse ........................................ AP-2γ-Deficient Mouse ............................. High-Chimeric Hai-1/Spint1(−/−) Mouse......................................................... St14 Transgenic Mouse.............................. ELA2 Overexpressing Transgenic Mouse ...................................... UBC-Taps Mouse....................................... Abca12-Disrupted Mouse .......................... BMP-Receptor-IB Transgenic Mouse ....... CB1R and CB2R Knockout Mouse ...........
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Mouse Models in Which Filaggrin Expression Is Altered by Chemicals or UV Exposure ........................................
71
Filaggrin in Other Animals .......................
72
References .................................................................
72
7.4.20 7.4.21 7.4.22 7.4.23 7.4.24 7.4.25 7.4.26 7.4.27 7.5
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7.6
70 70 71 71
69 69 69
7.1
K. Nakai, MD, PhD (*) • K. Yoneda, MD, PhD Y. Kubota, MD, PhD Department of Dermatology, Kagawa University, 1750-1 Ikenobe, miki-cho, Kita-gun, Kagawa 761-0793, Japan e-mail: [email protected]; [email protected]; [email protected]
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Introduction
The roles of human filaggrin in health and disease have been modeled with experimental animal models, mostly mice (Table 7.1). Mouse models have provided important inf
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