Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled tria
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Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial Liping Yang1,2* , Wenhua Ling2, Yun Qiu2, Yong Liu1, Li Wang1, Jing Yang1, Changyi Wang1 and Jianping Ma1
Abstract Background: Epidemiological studies have suggested that adiponectin is associated with the development of insulin resistance and type 2 diabetes. This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes. Methods: A total of 160 patients with prediabetes (n = 90) or newly diagnosed diabetes (n = 70) were randomly assigned to either the anthocyanins group or the placebo group for 12 weeks of intervention.Serum adiponectin, a set of biomarkers related to glucolipid metabolism, anthropometric parameters, dietary intake and physical activity were measured before and after intervention. Results: Anthocyanins increased serum adiponectin compared with placebo (net change 0.46 µg/mL, 95% CI [0.03, 0.90], p = 0.038) in the subjects with newly diagnosed diabetes. No significant difference in the change in adiponectin was observed between the two groups either in the overall subjects (0.02 µg/mL [− 0.32, 0.36], p = 0.906) or in prediabetes (− 0.35 µg/mL [− 0.85, 0.16], p = 0.174). Anthocyanins also decreased fasting glucose (− 0.5 mmol/L [− 1, − 0.04], p = 0.035) in the subjects with newly diagnosed diabetes, but no such change was observed in those with prediabetes. Conclusions: Anthocyanins supplementation for 12 weeks improved serum adiponectin and fasting glucose in patients with newly diagnosed diabetes, but not in patients with prediabetes. Trial registration: ClinicalTrials.gov, NCT02689765. Registered on 6 February 2016, https://clinicaltrials.gov/ct2/show/ NCT02689765. Keywords: Anthocyanin, Adiponectin, Prediabetes Highlights The First study to examine the effects of purified anthocyanins on serum adiponectin in patients with prediabetes and newly diagnosed diabetes.
*Correspondence: [email protected] 1 Center for Chronic Disease Control, NanShan, Shenzhen, People’s Republic of China Full list of author information is available at the end of the article
Anthocyanins increased serum adiponectin and decreased fasting glucose in patients with newly diagnosed diabetes, but not in prediabetes. Provide new evidence for anthocyanins in the treatment and prevention of type 2 diabetes.
Introduction The prevalence of type 2 diabetes mellitus (T2DM) in conjunction with its cardiovascular complications is becoming the most serious health challenge worldwide. Adiponectin, the most common adipokine, has been
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