Anti-inflammatory and In Silico Docking Studies of Heterophragma adenophyllum Seem Stem Constituents
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ORIGINAL ARTICLE
Anti-inflammatory and In Silico Docking Studies of Heterophragma adenophyllum Seem Stem Constituents Tareq Abu-Izneid,1 Zafar Ali Shah,2 Abdur Rauf ,3,16 Abdul Wadood,4 Saud Bawazeer,5 Naveed Muhammad,6 Mohamed A. El-Esawi,7 Fahad A. Alhumaydhi,8 Abdullah S. M. Aljohani,9 Eman El-Sharkawy,10 Mohammad S. Mubarak,11 Kuralay Isayeva,12 and Mohammad Ali Shariati13,14,15 Received 23 July 2020; accepted 24 August 2020
Abstract— Heterophragma adenophyllum is a traditional medicinal plant that has been
used as anti-inflammatory and to relief muscular tension. In the current research, four isolated constitutes namely lapacho (1), peshawaraquinone (2), indanone derivatives (3), α-lapachone (4) of H. adenophyllum were tested for anti-inflammatory effect using the carrageenan- and histamine-induced paw edema paradigm. The tested compounds (1–4) were evaluated for anti-inflammatory effect during the early and late phase of edema induction. In the early phase, all tested compounds (0.5 2.5 mg/kg each i.p.) demonstrated less than 50% effect, while in the later phase, compounds (2 and 3) demonstrated 85.66 and 89.87% attenuation. In addition, compounds (1–4) were subjected to histamine-induced inflammation, where compounds 2 and 3 exhibited excellent effects 86.87 and 89.98%, respectively at 5 mg/kg after the 2nd hour of administration, whereas compounds 1 and 4 did not exhibit any significant effect as compared with the negative control. Molecular docking results revealed a very high
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Pharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain Campus, United Arab Emirates 2 Department of Biochemistry, Agriculture University of Peshawar, Peshawar, KPK, Pakistan 3 Department of Chemistry, University of Swabi, Anbar, KPK, Pakistan 4 Department of Biochemistry, Abdul Wali Khan, University Mardan, Mardan, KPK, Pakistan 5 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, P.O. Box 42, Makkah, Saudi Arabia 6 Department of Pharmacy, Abdul Wali Khan University, Mardan, KPK, Pakistan 7 Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt 8 Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia 9 Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia
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Chemistry Department, Faculty of Science, Northern Borders University, Arar, Saudi Arabia 11 Department of Chemistry, The University of Jordan, Amman, 11942, Jordan 12 S. Toraighyrov Pavlodar State University, Pavlodar, Kazakhstan 13 Laboratory of Biological Control and Antimicrobial Resistance, Orel State University named after I.S. Turgenev, Orel City, 302026, Russia 14 K.G. Razumovsky Moscow State University of Technologies and Management (the First Cossack University), Moscow, Russian Federation 15 Kazakh Research Institute of Processing and Food Industry (Semey Branch), Semey, Kazakhstan 16 To whom correspondence should be addressed at Department of Chemistry, Unive
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