Antibacterials
- PDF / 141,868 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 33 Downloads / 173 Views
1
S
Haemorrhagic colitis: 11 case reports An observational study identified six women and five men aged 22–51 years with sinusitis (8 patients) or tonsillitis (3) who developed haemorrhagic colitis during treatment with antibiotics [routes and dosages not stated]. The patients developed bloody diarrhoea between 1–14 days after the first dose of sulbactam/ampicillin (10 patients) or amoxicillin/clavulanic acid (1). Four patients were receiving NSAIDs at the time of diagnosis. WBC counts ranged from 7.6–17.2 × 109/L, and serum CRP levels ranged from 18–322 mg/L. Five patients had Klebsiella oxytoca-positive Clostridium difficile-negative haemorrhagic colitis, while all six patients who tested positive for C difficile toxin A + B were also found to have K oxytoca. Sulbactam/ampicillin was discontinued. Ten patients received empirical treatment with metronidazole, and one patient received symptomatic treatment with IV fluids. Time to recovery ranged from 2–21 days. During 2–7 years’ follow-up, ten patients had no recurrence of haemorrhagic colitis. The remaining patient, a 31-year-old woman with a history of antibiotic-associated bloody diarrhoea, experienced recurrent episodes of bloody diarrhoea and was diagnosed with ulcerative colitis; she was subsequently cured with colectomy. Author comment: "In some of the patients with AAHC [antibiotic-associated haemorrhagic colitis], K. oxytoca may coexist with C. difficile toxin A + B." Yilmaz M, et al. Prospective observational study on antibiotic-associated bloody diarrhea: Report of 21 cases with a long-term follow-up from Turkey. European Journal of Gastroenterology and Hepatology 24: 688-694, No. 6, Jun 2012. Available from: URL: http://dx.doi.org/10.1097/MEG.0b013e328352721a 803074187 Turkey
0114-9954/10/1412-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 28 Jul 2012 No. 1412
Data Loading...
