Antibiotics-related adverse events in the infectious diseases department of a French teaching hospital: a prospective st
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ARTICLE
Antibiotics-related adverse events in the infectious diseases department of a French teaching hospital: a prospective study J. Courjon & C. Pulcini & E. Cua & K. Risso & F. Guillouet & E. Bernard & P.-M. Roger
Received: 28 March 2013 / Accepted: 26 June 2013 # Springer-Verlag Berlin Heidelberg 2013
Abstract Antibiotics are a significant cause of adverse events (AE), but few studies have focused on prescriptions in hospitalized patients. In infectious diseases departments, the high frequency and diversity of antibiotics prescribed makes AE post-marketing monitoring easier. The aim of our study was to assess the incidence and type of AE in the infectious diseases department of a French teaching tertiarycare hospital. The main characteristics of each hospitalization, including all antibiotics prescribed and any significant AE were recorded prospectively in the medical dashboard of the department. We included all patients having suffered an AE due to systemic antibiotics between January 2008 and March 2011. Among the 3963 hospitalized patients, 2682 (68 %) received an antibiotic and 151/2682 (5.6 %) suffered an AE. Fifty-two (34 %) AE were gastrointestinal disorders, 32 (21 %) dermatological, 20 (13 %) hepatobiliary, 16 (11 %) renal and urinary disorders, 13 (9 %) neurological and 11 (7 %) blood disorders. Rifampin, fosfomycin, cotrimoxazole and linezolid were the leading causes of AE. Sixty-two percent of the antibiotics causing an AE were stopped and 38 % were continued (including 11 % with a dose modification). Patients suffering from AE had an increased length of stay (18 vs 10 days, P
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