Antimicrobial Stewardship

Antimicrobial stewardship programs are becoming more common, but the experience specifically in hematologic neutropenic patients is scarce. Concerns about poor outcomes due to immune deficiency, and lack of specific data have prevented so far a comprehens

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Oliver A. Cornely Martin Hoenigl   Editors

Infection Management in Hematology

Hematologic Malignancies Series Editor Martin Dreyling Großhadern Hospital,Medicine III Ludwig Maximilians University of Munich München Germany

More information about this series at http://www.springer.com/series/5416

Oliver A. Cornely  •  Martin Hoenigl Editors

Infection Management in Hematology

Editors Oliver A. Cornely Department I for Internal Medicine CECAD Translational Research Institute University Hospital of Cologne Cologne Germany

Martin Hoenigl Department of Internal Medicine Medical University of Graz Graz Steiermark Austria Department of Medicine University of California San Diego San Diego California USA

ISSN 2197-9766     ISSN 2197-9774 (electronic) Hematologic Malignancies ISBN 978-3-030-57316-4    ISBN 978-3-030-57317-1 (eBook) https://doi.org/10.1007/978-3-030-57317-1 © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

Infections are major causes of morbidity and mortality in patients with hematological malignancies, particularly in those with prolonged neutropenia and recipients of hematopoietic stem cell transplantation (HSCT). Successful management of infectious diseases in this setting often necessitates not only expert knowledge in infectious diseases but also expertise in diagnosis and treatment of the underlying hematologic diseases. In the hematologic setting differential diagnosis of presumed infection always includes multiple different pathogens, as bacterial, fungal, viral, and parasitic infections occur. In addition, the underlying hematologic disease can sometimes mimic an infectious disease process, with similar radiological and