Antipsychotics
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Acute dystonic reaction: 21 case reports In a retrospective chart review-based cohort study of 441 patients who attended Ankara Yildirim Beyazit University’s Department of Child and Adolescent Psychiatry, Turkey and were treated with antipsychotics between 1 July 2015 and 1 January 2017, 21 patients [ages and sexes not stated] were described, who developed acute dystonic reaction (ADR) during antipsychotics treatment with aripiprazole, chlorpromazine, haloperidol, olanzapine, quetiapine, risperidone or zuclopenthixol [routes, dosages and outcomes not stated; not all durations of treatments to reactions onsets stated]. The patients, who had unspecified psychotic disorders, started receiving antipsychotic drug treatment with risperidone (n=1); olanzapine (n=1), long-acting injectable risperidone (n=1); haloperidol (n=1); zuclopenthixol [zuclopenthixol decanoate; n=1]; olanzapine and aripiprazole (n=1); risperidone and olanzapine (n=3); risperidone and long-acting injectable risperidone (n=2); risperidone and aripiprazole (n=1); olanzapine and quetiapine (n=1); long-acting injectable risperidone and olanzapine (n=1); risperidone and haloperidol (n=1); olanzapine and zuclopenthixol [zuclopenthixol decanoate; n=1]; haloperidol and chlorpromazine (n=1); long-acting injectable risperidone and aripiprazole (n=1); olanzapine and chlorpromazine (n=1); aripiprazole and chlorpromazine (n=1); and risperidone and zuclopenthixol [zuclopenthixol decanoate; n=1]. However, 1–5 days after the initiation of antipsychotics treatment, the patients developed ADR. Out of 21 patients, antipsychotic therapy was discontinued in seven patients and antipsychotic therapy dose was decreased in seven patients. All 21 patients were treated with biperiden. Tural Hesapcioglu S, et al. Frequency and Correlates of Acute Dystonic Reactions after Antipsychotic Initiation in 441 Children and Adolescents. Journal of Child and Adolescent Psychopharmacology 30: 366-375, No. 6, Jul 2020. Available from: URL: http://doi.org/10.1089/cap.2019.0123 803518881
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Reactions 5 Dec 2020 No. 1833
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