Antirheumatic Therapy: Actions and Outcomes

Our goal for this book is to examine the contemporary therapy of rheumatoid arthritis (RA) from the increasingly important perspective of impact upon quality of life, costs and long-term health outcomes. For too long the focus has been on short­ term, sym

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Series Editor Prof. Michael J. Parnham PhD Senior Scientific Advisor PLIVA Research Institute Ltd. Prilaz baruna Filipovica 29 HR-10000 Zagreb Croatia

Advisory Board G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA) M . Pairet (Boehringer Ingelheim Pharma KG , Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)

Forthcoming titles: NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer,

G.Z. Feuerstein, Z. Zukowska (Editors), 2005 Turning up the Heat on Pain: Vanilloid Receptors in Pain and Inflammation,

A.B Malmberg, K.R. Bley (Editors), 2005 Regulatory T-Cells in Inflammation, L. Taams, A.N. Akbar, M .H.M. Wauben (Editors), 2005 Sodium Channels, Pain, and Analgesia, K. Coward, M . Baker (Editors), 2005 Complement and Kidney Disease, P.E Zipfel (Editor), 2005

(Already published titles see last page.)

Antirheumatic Therapy: Actions and Outcomes

Richard O. Day Daniel E. Furst Piet L.C.M. van Riel Barry Bresnihan Editors

Bitkhauser Verlag Basel - Boston' Berlin

Editors Richard O. Day Department of Clinical Pharmacology and Toxicology St. Vincent's Hospital Sydney Victoria Street Darlinghurst, Sydney, NSW2010 Australia

Daniel E. Furst CarlM. Pearson Professor of Rheumatology University of California at LosAngeles 1000 Veteran Ave Rm 32-59 LosAngeles, CA 90025-1670 USA

Piet L.C.M. van Riel University Hospital Nijmegen 546 Dept. of Rheumatology P.O. Box9101 6500 HB Nijmegen The Netherlands

Barry Bresnihan Department of Rheumatology St Vicent's University Hospital Elm Park Dublin 4 Ireland

A CIPcatalogue record for this book is available from the Library of Congress, Washington D.C., USA

Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek liststhis publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb .de

The publisherand editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective usermust check its accuracy by consulting other sources of reference in each individual case. The useof registered names, trademarks etc. in this publication, evenif not identifiedassuch, doesnot imply that they are exempt from the relevant protective lawsand regulations or free for general use.

ISBN 3-7643-6595-1 Birkhauser Verlag, Basel- Boston - Berlin Thiswork is subject to copyright. All rightsare reserved , whether the whole or part of the material is concerned, specifically the rightsof translation, reprinting, re-use of illustrations, recitation , broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Forany kind of use, permission of the copyright owner must be obtained.

© 2005 Btrkhauser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Partof Springer Science-Business Media Printed on acid-free paperproduced from chlorine-free pulp. TCF 00 Coverdesign: Markus Etterich, Basel Printed in Germany ISBN 3-7643-6595-1 987654321

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