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Fatal acute graft versus host disease: case report In a report involving 20 thalassaemia major patients, a patient [age and sex not stated] was described, who developed fatal event of severe acute steroid-resistant graft versus host disease (GVHD) following administration of antithymocyte-globulin, busulfan and cyclophosphamide as a conditioning chemotherapy regimen for allogenic haematopoietic stem cell transplantation (HSCT). The patient, who had been diagnosed with thalassaemia major, underwent allogeneic HSCT following administration of conditioning chemotherapy regimen comprising antithymocyte-globulin, busulfan and cyclophosphamide [dosages and routes not stated]. Subsequently, the patient developed severe acute steroid-resistant GVHD and eventually died of it [durations of treatments to reaction onset not stated]. Loney G, et al. Bu/CY/ATG vs treo/thio/flu conditioning regimen for allogenic HSCT in thalassemia major patients. Indian Journal of Hematology and Blood Transfusion 35 803502836 (Suppl. 1): S137 abstr. 20, Oct 2019. Available from: URL: http://doi.org/10.1007/s12288-019-01207-5 [abstract]

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Reactions 26 Sep 2020 No. 1823