Anxiety and Anxiolytic Drugs
The present volume gives a comprehensive overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anx
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Handbook of Experimental Pharmacology, Vol. 169
Anxiety and Anxiolytic Drugs Editor: Florian Holsboer and Andreas Ströhle
© Springer-Verlag Berlin Heidelberg 2005 Printed in The Netherlands. Not for Sale.
Reprint only allowed with permission from Springer Verlag.
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Handbook of Experimental Pharmacology
Volume 169 Editor-in-Chief K. Starke, Freiburg i. Br. Editorial Board G.V. R. Born, London M. Eichelbaum, Stuttgart D. Ganten, Berlin F. Hofmann, München W. Rosenthal, Berlin G. Rubanyi, Richmond, CA
Anxiety and Anxiolytic Drugs Contributors A. Bilkei-Gorzo, E.B. Binder, D.S. Charney, F. Crestani, R.J. Daher, W. Danysz, C.H. Duman, R.S. Duman, F. Holsboer, M.E. Keck, R. Landgraf, K.P. Lesch, R. Lieb, K.-M. Lin, M.T. Lin, A.C.E. Linthorst, N.C.P. Low, H. Möhler, M.B. Müller, K.R. Merikangas, J.R. Nash, A. Neumeister, D.J. Nutt, F. Ohl, C.G. Parsons, U. Rudolph, A. Ströhle, C.W. Turck, K. Vogt, C.T. Wotjak, R. Yehuda, W. Zieglgänsberger, A. Zimmer Editors
Florian Holsboer and Andreas Ströhle
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Professor Dr. Dr. Florian Holsboer Max-Planck-Institut für Psychiatrie Kraepelinstr. 10 80804 München, Germany e-mail: [email protected] Priv.-Doz. Dr. Andreas Ströhle Klinik für Psychiatrie und Psychotherapie Charité Campus Mitte Charité – Universitätsmedizin Berlin Schuhmannstr. 20/21 10117 Berlin, Germany e-mail: [email protected] With 139 Figures and 30 Tables
ISSN 0171-2004 ISBN-10 3-540-22568-4 Springer Berlin Heidelberg New York ISBN-13 978-3-540-22568-3 Springer Berlin Heidelberg New York Library of Congress Control Number: 2004115902 This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science + Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2005 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Dr. P. Roos Desk Editor: S. Dathe Cover design: design&production GmbH, Heidelberg, Germany Typesetting and production: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig, Germany Printed on acid-free paper 27/3151-YL - 5 4 3 2 1 0
Preface
Research on anxi
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