Aortopathic effect of androgenic anabolic steroids
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ORIGINAL INVESTIGATION
Aortopathic effect of androgenic anabolic steroids Mohammad Ali Babaee Bigi1 · Firouzeh Abtahi1 · Zahra Mehdipour Namdar1 · Anis Amirhakimi1 · Alireza Hosseinpour1 · Shahab Shahrzad2 · Amir Aslani1 Received: 3 August 2020 / Revised: 19 September 2020 / Accepted: 1 October 2020 © Japanese Society of Echocardiography 2020
Abstract Background Anabolic androgens have been reported to be associated with cardiovascular complications. One study revealed that increase in vascular stiffness in bodybuilders is associated with anabolic androgens and improvement in vascular function may occur following anabolic androgens discontinuation. The aim of this study was to investigate any possible relation between aortic elastic properties and anabolic androgens. Methods Study population was divided into 3 groups: Group-1 [n = 35] consisted of bodybuilders who denied any current or previous use of anabolic androgens. Group-2 [n = 18] was bodybuilders with regular using of anabolic androgens for at least 2 year prior to the start of our study. Group-3 was 13 healthy age-matched sedentary men as a control group. Cardiac echocardiography was performed in the bodybuilders and controls and indexes of aortic function were calculated. Results Aortic stiffness was approximately twofold higher in anabolic androgens user bodybuilders compared with drugfree bodybuilders [P
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