Apoptosis: Biology and Mechanisms
The past few years have seen rapid progress in apoptosis research. This volume deals with many of the recent advances made in uncovering the molecular and cellular basis of apoptosis, with particular emphasis to the role of apoptosis in normal biological
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Springer-Verlag Berlin Heidelberg GmbH
S. Kumar
(Ed.)
Apoptosis: Biology and
Mechanisms
With 13 Figures
Dr. Sharad Kumar Hanson Centre for Cancer Research Institute of Medical and Veterinary Science P.O. Box 14, Rundle Mall Adelaide, SA 5000 Australia
ISSN 0080-1844 ISBN 978-3-662-21623-1 Library of Congress Cataloging-in-Publication Data Apoptosis: biology and mechanisms 1 S. Kumar (ed.). p. cm. - (Results and problems in celi differentiation; 23) Includes bibliographical references and index. ISBN 978-3-540-69184-6 (eBook) ISBN 978-3-662-21623-1 DOI 10.1007/978-3-540-69184-6 1. Apoptosis. !. Kumar, Sharad. II. Series. [DNLM: 1. Apoptosis. W1RE248X v.23 1998] QH607.R4 voi. 23 [QH6714] 571.8'35 s-dc21 [571.9'36] This work is subject to copyright. Ali rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag Berlin Heide1berg GmbH. Violations are liable for prosecution under the German Copyright Law. © Springer-Ver1ag Berlin Heide1berg 1999
Originally pnb1ished by Springer-Ver1ag Berlin Heide1berg New York in 1999 Softcover reprint of the hardcover 1st edition 1999 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover Design: Meta Design, Berlin Typesetting: Best-set Typesetter Ltd., Hong Kong SPIN 10571118 39/3137- 5 4 3 2 1 O- Printed on acid-free paper
Preface
Apoptosis is currently one of the fastest moving fields in biology with spectacular progress made over the past few years in delineating the molecular mechanisms which underlie this process. It is now indisputable that apoptosis plays an essential role in normal cell physiology and that aberrant apoptosis can manifest itself in a variety of human disorders. Published in two parts (Volumes 23 and 24 of the series entitled Results and Problems in Cell Differentiation), this is an attempt to bring together many different aspects of apoptosis. Given that this is such a vast and rapidly expanding field, it is almost impossible to cover everything that is now known about apoptosis in two short books, but 1 hope these volumes prove to be a guidepost, providing basic essential information on the biology and molecular mechanisms of apoptosis and its implications in some human diseases. As a significant am ount of new information on apoptosis is emerging every week, it is unrealistic to expect that by the time these two books are published, all the articles will deliver up-to-date information. Nevertheless, 1 believe that
