Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents
This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinician
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Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents
Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents
Michael W. Jann • Scott R. Penzak Lawrence J. Cohen Editors
Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents
Editors Michael W. Jann Department of Pharmacotherapy University of North Texas System College of Pharmacy Fort Worth, TX USA
Lawrence J. Cohen Department of Pharmacotherapy University of North Texas System College of Pharmacy Fort Worth, TX USA
Scott R. Penzak Department of Pharmacotherapy University of North Texas System College of Pharmacy Fort Worth, TX USA
ISBN 978-3-319-27881-0 ISBN 978-3-319-27883-4 DOI 10.1007/978-3-319-27883-4
(eBook)
Library of Congress Control Number: 2016932526 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Adis is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface and Acknowledgments
The primary purpose of the Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents text is to offer students, clinicians, scientists, and members of the pharmaceutical industry a comprehensive yet practical information resource for medications that affect the central nervous system (CNS). Part 1 presents the background for the pharmacokinetic and pharmacodynamic principles for agents that must reach the CNS to produce their clinical actions. Drug development and clinical application for the psychopharmacological agents have progressed to incorporate biomarkers, such as positron emission tomography (PET) scans, pharmacogenomics, and sophisticated mathematical modeling with population pharmacometrics. These chapters provide the readers with a foundational background of these exciting areas. Each
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