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Tardive dyskinesia and parkinsonism: case report A 59-year-old man developed tardive dyskinesia following treatment with aripiprazole. Further, he developed parkinsonism following treatment with valbenazine [routes not stated; not all dosages, durations of treatments to reactions onsets stated]. The man had been receiving aripiprazole for schizophrenia for two years. In May 2018, he presented for stereotypical orobuccolingual movements. Tardive dyskinesia secondary to aripiprazole was diagnosed. The man’s treatment with aripiprazole was discontinued. He was started on deutetrabenazine. His tardive dyskinesia improved, but he had extreme drowsiness. Therefore, deutetrabenazine was discontinued. He was started on valbenazine 40mg daily. The tardive dyskinesia improved. Following 3 weeks of the valbenazine, he developed resting tremor in the upper right extremity with shuffling gait. Examination exhibited asymmetrical parkinsonism, anosmia and depression. Valbenazine was discontinued. His parkinsonism resolved. However, tardive dyskinesia reappeared. Therefore, he was again started on low dose valbenazine along with levodopa. At one-month follow-up in the clinic, his tardive dyskinesia improved and parkinsonism resolved. Vasireddy RP, et al. Parkinsonism secondary to use of valbenazine and reversal with the addition of levodopa: A case report. Neurology 94 (Suppl.): abstr. 1183, No. 15, 14 803511477 Apr 2020. Available from: URL: https://n.neurology.org/content/94/15_Supplement/1183 [abstract]

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Reactions 31 Oct 2020 No. 1828