• PDF / 170,147 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 103 Downloads / 197 Views

DOWNLOAD

REPORT

---

1 S

Osteonecrosis of the jaw: case report A 52-year-old man developed osteonecrosis of the jaw during treatment with arsenic trioxide and tretinoin for acute promyelocytic leukaemia. The man, who had unmated sleep apnea syndrome, obesity, balanced type II diabetes, triple coronary bypass and dental focal infection, started receiving urgent chemotherapy with tretinoin [all-trans retinoic acid] 100mg and arsenic trioxide 17mg [routes not stated] for acute promyelocytic leukaemia. Additionally, he had been receiving treatment with various concomitant medications. Later on, he was hospitalised for his second chemotherapy, and suddenly revealed a febrile peak (RBC 2.7 T/L, WBC 1780 G/L and blood platelet 132 G/L). Subsequently, a cervico thoraco abdomino pelvic CT-scan revealed 28 (tooth) in the left maxillary sinus. This tooth was the only infectious gateway noted. Additionally, a lysis of the posterior bone wall of the sinus and a bony sequestrum was noted [time to reaction onset not stated]. The man was then treated with probabilistic antibiotic including piperacillin/tazobactam [Tazocilline] and linezolid [Zyvoxid] for 21 days Therapy with arsenic trioxide was discontinued, while tretinoin was maintained. Thereafter, he underwent a removal of the bony sequestrum with functional endoscopic surgery. A maxillary sinus evacuation with bacteriological and mycological analysis and the avulsion of the tooth was done with intraoral approach. Also, all dental infectious foci were eliminated through multiple avulsions. Following the surgery, a level I analgesic, chlorhexidine mouthwash, nose washing with physiological saline and a cold liquid diet were prescribed. His bacteriological and mycological samples were found to be negative. It was possible to resume arsenic trioxide 2 days after the surgery. He returned home 8 days after the surgery. Derache A, et al. Osteonecrosis of the jaw induced by arsenic trioxide therapy in a leukemia patient: A rare case report and literature review. Oral Oncology 109: 104725, Oct 803507222 2020. Available from: URL: http://doi.org/10.1016/j.oraloncology.2020.104725

0114-9954/20/1826-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 17 Oct 2020 No. 1826