ASO Author Reflections: Validation Based on Low-Volume Metastasis of the Sentinel Lymph Node Biopsy in Early-Stage Cervi
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ASO AUTHOR REFLECTIONS
ASO Author Reflections: Validation Based on Low-Volume Metastasis of the Sentinel Lymph Node Biopsy in Early-Stage Cervical Cancer Benedetta Guani, MD1,2 1
, and Patrice Mathevet, PhD, MD1,2
Department of Gynecology, CHUV, Lausanne, Switzerland; 2Faculty of Medicine, UNIL, Lausanne, Switzerland
PAST Sentinel lymph nodes normally are examined with ultrastaging, and non-sentinel nodes usually are examined only with routine technique. Low-volume metastasis (micrometastasis and isolated tumor cells) can be missed by classical pathologic analysis. For ability to consider the sentinel node technique as safe, clinicians must be sure that its negative predictive value (NPV) is 100%. PRESENT To validate the sentinel lymph node technique from the lowvolume metastasis point of view, the ‘‘Histopathological validation of sentinel lymph nodes study’’,1 currently in press, included an ultra-staging examination of all nodes, sentinel nodes, and non-sentinel nodes of all Senticol 1 patients.2 To date, the discovery of these low-volume metastases can imply therapeutic decisions that can modify the patient’s management even if their clinical significance remains uncertain. This study1 can confirm that the NPV is 100% for optimal mapping with bilateral detection, which also is the low-volume metastasis point of view. FUTURE The sentinel node technique is a safe technique. The future lies in standard use of the sentinel node technique for early-stage cervical cancer patients instead of
Ó The Author(s) 2020 First Received: 26 October 2020 Accepted: 27 October 2020 B. Guani, MD e-mail: [email protected]
lymphadenectomy. Clinicians are awaiting the results of Senticol 33 for definitive validation of this technique.
FUNDING Lausanne.
Open access funding provided by University of
DISCLOSURE
There are no conflicts of interest.
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REFERENCES 1. Mathevet P, Guani B, Ciobanu A, et al. Histopathologic validation of the sentinel node technique in early-stage cervical cancer patients. Ann Surg Oncol. 2020. https://doi.org/10.1245/s10434020-09328-2. 2. Le´curu F, Mathevet P, Querleu D, et al. Bilateral negative sentinel nodes accurately predict absence of lymph node metast
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