Assessment of Cardiac Arrhythmic Risk in Children With Covid-19 Infection
- PDF / 465,447 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 76 Downloads / 140 Views
ORIGINAL ARTICLE
Assessment of Cardiac Arrhythmic Risk in Children With Covid‑19 Infection İbrahim Ece1 · Mücahit Koçoğlu1 · Ahmet Vedat Kavurt1 · Denizhan Bağrul1 · A. Esin Kibar Gül1 · Serhat Koca1 · İbrahim İlker Çetin2 · A. Nur Özkaya Parlakay3 · Sevcan Aksoy4 Received: 30 May 2020 / Accepted: 24 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Coronavirus disease of 2019 (COVID-19) is a cause of significant morbidity and mortality worldwide. Although COVID-19 clinical manifestations are mainly respiratory, major cardiac complications are being reported. The mechanism of cardiac injury and arrhythmias is unclear. Also, drugs currently used to treat the COVID-19 may prolong the QT interval and may have a proarrhythmic propensity. The study aims to investigate the effects of COVID-19 infection with asymptomatic and mild symptoms on trans-myocardial repolarization parameters in children without treatment. A total of 105 COVID-19 patients were compared with 40 healthy children. The patient and control group data were compared by calculating the QT interval, corrected QT (QTc), QT dispersion (QTd), QTc dispersion (QTcd), Tp-e, Tp-e dispersion, Tp-e/QT ratio, and Tp-e/QTc ratio on the 12-lead surface electrocardiogram. The mean age was determined as 11.2 ± 0.3 years in the patient group, and 10.8 ± 2.1 years in the control group. In the COVID-19 group, QTd, QTcd, Tp-e, Tp-e dispersion, Tp-e/QT ratio and Tp-e/ QTc ratio were statistically higher than the control group. The ventricular repolarization was impaired even in asymptomatic children with COVID-19 infection. These results suggest the need to further assess the long terms risks of prolonged QT dispersion in the setting of COVID-19 infection. Keywords COVID-19 · Myocardial damage · Arrhythmia · Cardiovascular system
Introduction A novel coronavirus, now designated SARS-CoV-2 (COVID-19), was identified as the cause of an outbreak of acute respiratory illness in Wuhan, a city in the Hubei Province of China [1]. Presentations of COVID-19 infection have ranged from asymptomatic/mild symptoms to severe * İbrahim Ece [email protected] 1
Faculty of Medicine, Department of Pediatric Cardiology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey
2
Faculty of Medicine, Department of Pediatric Cardiology, Ankara City Hospital, University of Yıldırım Beyazıt, Ankara, Turkey
3
Faculty of Medicine, Department of Pediatric Infection, Ankara City Hospital, University of Yıldırım Beyazıt, Ankara, Turkey
4
Faculty of Medicine, Department of Pediatrics, Ankara City Hospital, University of Health Sciences, Ankara, Turkey
illness. COVID-19 infection appears to be milder in children than in adults, although severe cases have been reported [2]. Acute myocardial damage, arrhythmia, and cardiogenic shock have been demonstrated in adult COVID-19 infection. Arrhythmias may be the first clinical sign of COVID-19 infection. Besides drugs such as hydroxychloroquine (HCQ) and azithromycin which are use
Data Loading...
