Assessment of cardiac function in absence of congenital and acquired heart disease in patients with Down syndrome
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Assessment of cardiac function in absence of congenital and acquired heart disease in patients with Down syndrome Sevket Balli, Ilker Kemal Yucel, Ayse Esin Kibar, Ibrahim Ece, Eylem Sen Dalkiran, Sukru Candan Istanbul, Turkey
Methods: A total of 115 patients with DS between 6 and 13 years of age with clinically and anatomically normal heart and 55 healthy children were included in this cross-sectional study. DS was diagnosed by a karyotype test. Patients with mosaic type were not included in this study. Systolic and diastolic functions were evaluated by echocardiography. Results: Pulsed waved Doppler transmitral early/late inflow velocity (E/A), tissue Doppler mitral annular early/ late diastolic peak velocity (Ea/Aa), transtricuspid E/A and tricuspid valve annulus Ea/Aa, pulmonary venous Doppler systolic/diastolic (S/D) wave ratio were lower in patients with Down syndrome than in the control group (P=0.04, P=0.001, P
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