Association Among Blood Transfusion, Postoperative Infectious Complications, and Cancer-Specific Survival in Patients wi
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ORIGINAL ARTICLE – GASTROINTESTINAL ONCOLOGY
Association Among Blood Transfusion, Postoperative Infectious Complications, and Cancer-Specific Survival in Patients with Stage II/III Gastric Cancer After Radical Gastrectomy: Emphasizing Benefit from Adjuvant Chemotherapy Hua Xiao, MD1,2 , Yanping Xiao, MD3, Pan Chen, MD1, Hu Quan, MD1, Jia Luo, MD1, and Gang Huang, MD2,4 1
Department of Hepatobiliary and Intestinal Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; 2Department of Gastroduodenal and Pancreatic Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; 3Department of Admissions and Employment, Changsha Health Vocational College, Changsha, Hunan, China; 4Department of Orthopedics, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
ABSTRACT Objectives. This study was designed to investigate the potential additive influence of perioperative blood transfusion (BTF) and postoperative infections on cancerspecific survival (CSS) in patients with stage II/III gastric cancer (GC) after radical gastrectomy. Methods. The medical records of 2114 consecutive stage II/III GC patients who underwent curative resection and planned to receive adjuvant chemotherapy (AC) were retrospectively reviewed. The independent predictive factors for infections were identified using univariate and
Electronic supplementary material The online version of this article (https://doi.org/10.1245/s10434-020-09102-4) contains supplementary material, which is available to authorized users. Hua Xiao and Yanping Xiao are co-first authors and contributed equally to this work. Ó The Author(s) 2020 First Received: 9 June 2020 Accepted: 16 August 2020 J. Luo, MD e-mail: [email protected] G. Huang, MD e-mail: [email protected]
multivariate analyses. Cox regression analysis was used to assess any associations between BTF, infection and CSS. Results. A total of 507 (24.0%) received perioperative BTF and 148 (7.0%) developed infections with BTF being identified as an independent predictor for infections. Both BTF and infections independently predicted poor CSS (hazard ratio [HR]: 1.193, 95% confidence interval [CI] 1.007–1.414; HR 1.323, 95% CI 1.013–1.727) and an additive effect was confirmed as patients who had both BTF and infection had even worse CSS. Further stratified analyses showed that complete AC (C 6 cycles) could significantly improve CSS in patients who had BTF and/or infection, which was comparable to those without BTF and/or infection (P = 0.496). Conclusions. Infection was the most common complication after gastrectomy and BTF was identified as an independent risk factor. BTF was associated with shorter CSS in stages II/III GC, independent of infections, and receiving BTF and developing infections had an additive effect that was associated with even worse CSS. Howev
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