Association between adipocyte fatty acid-binding protein with left ventricular remodelling and diastolic function in typ
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ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
Association between adipocyte fatty acid‑binding protein with left ventricular remodelling and diastolic function in type 2 diabetes: a prospective echocardiography study Mei‑Zhen Wu1,2†, Chi‑Ho Lee3†, Yan Chen4, Shuk‑Yin Yu2, Yu‑Juan Yu1,2, Qing‑Wen Ren1,2, Ho‑Yi Carol Fong3, Pui‑Fai Wong2, Hung‑Fat Tse1,2, Siu‑Ling Karen Lam3 and Kai‑Hang Yiu1,2*
Abstract Background: The relationship between adipocyte fatty acid-binding protein (AFABP) and cardiac remodelling has been reported in cross-sectional studies, although with conflicting results. Type 2 diabetes mellitus (T2DM) is associ‑ ated with left ventricular (LV) hypertrophy and diastolic dysfunction, as well as elevated circulating AFABP levels. Here we investigated prospectively the association between AFABP with the longitudinal changes of cardiac remodelling and diastolic dysfunction in T2DM. Methods: Circulating AFABP levels were measured in 176 T2DM patients without cardiovascular diseases (CVD) at baseline. All participants received detailed transthoracic echocardiography both at baseline and after 1 year. Multi‑ variable linear and Cox regression analyses were used to evaluate the associations of circulating AFABP levels with changes in echocardiography parameters and incident major adverse cardiovascular events (MACE), respectively. Results: The median duration between baseline and follow-up echocardiography assessments was 28 months. Higher sex-specific AFABP quartiles at baseline were associated with increase in LV mass and worsening of average E/e′ (all P
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