Association Between Fasting Blood Glucose and All-Cause Mortality in a Rural Chinese Population: 15-Year Follow-Up Cohor

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ORIGINAL RESEARCH

Association Between Fasting Blood Glucose and AllCause Mortality in a Rural Chinese Population: 15-Year Follow-Up Cohort Study Nannan Cheng . Yue Zhang . Jie Yang . Jingyi Li . Lijing Ye . Ziyi Zhou . Zhuo Wang . Lishun Liu . Yun Song . Zhibo Yang . Guiping She . Xue Bai . Xiao Huang . Xiaoshu Cheng . Genfu Tang . Binyan Wang . Xianhui Qin . Pierre Zalloua . Fangrong Yan

. Xiping Xu

Received: August 10, 2020 / Accepted: September 10, 2020 Ó The Author(s) 2020

ABSTRACT Introduction: The worldwide prevalence of diabetes has been increasing for decades; diabetes can lead to serious health problems and even death, but the effects of maintaining low fasting blood glucose (FBG) remain Digital Features To view digital features for this article go to: https://doi.org/10.6084/m9.figshare.12932966. Electronic supplementary material The online version of this article (doi:https://doi.org/10.1007/ s13300-020-00927-6) contains supplementary material, which is available to authorized users. N. Cheng  Y. Zhang  J. Yang  J. Li  L. Ye  F. Yan (&) State Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 210009, China e-mail: [email protected] Z. Zhou  Z. Wang  L. Liu  Y. Song  X. Xu (&) Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China e-mail: [email protected]

controversial. The purpose of this study was to investigate the relationship between FBG levels and all-cause mortality in a long-term follow-up cohort and to find a relatively safe range of FBG levels. Methods: This study included 17,902 adults from a community-based cohort study in rural China who were prospectively followed from 2003 to 2018. Generalized estimating equations were used to evaluate the association between FBG and all-cause mortality, adjusting for perX. Bai The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China X. Huang  X. Cheng Department of Cardiovascular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China Y. Song  G. Tang  B. Wang School of Health Administration, Anhui Medical University, Hefei, China B. Wang Shenzhen Evergreen Medical Institute, Shenzhen, China

Z. Yang Chinese Medicine Hospital of Zhaotong, Zhaotong, Yunnan, China

X. Qin  X. Xu National Clinical Research Study Center for Kidney Disease, the State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China

G. She The Second Affiliated Hospital of Shaoyang University, Shaoyang, Hunan, China

P. Zalloua School of Medicine, Lebanese American University, Byblos, Lebanon

Diabetes Ther

tinent covariates and auto-correlations among siblings. Results: A total of 1053 (5.9%) deaths occurred during 15 years of follow-up. There was a significant U-shaped association between all-cause mortality and FBG. Compared with the r