Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis
- PDF / 922,220 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 107 Downloads / 228 Views
SYSTEMATIC REVIEW
Open Access
Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis Jian-qiao Hong†, Yang-xin Wang†, Si-hao Li, Guang-yao Jiang, Bin Hu, Yu-te Yang, Jia-hong Meng and Shi-gui Yan*
Abstract Objective: Several studies have been performed to investigate the association between SMAD3 gene polymorphism and osteoarthritis (OA), but the results were inconclusive. This study aims to determine whether SMAD3 polymorphism is associated with risk of OA. Method: A comprehensive literature search in PubMed, Embase, and ISI Web of Science for relevant studies was performed. After extracting data from eligible studies, we chose the fixed or random effect model according to the heterogeneity test. Estimation of publication bias and sensitivity analysis were conducted to confirm the stability of this meta-analysis. Results: In total, 10 studies from 6 articles with 5093 OA patients and 5699 controls were enrolled in this meta-analysis. The combined results revealed significant association between SMAD3 rs12901499 polymorphism and the risk of OA (allele model: OR 1.21, 95% CI 1.07–1.38). Subgroup analysis revealed that G allele increased the risk of OA in Caucasians, but not in Asians (allele model: Caucasians: OR 1.31, 95% CI 1.18–1.44; Asians: OR 1.24, 95% CI 0.95–1.61). And the pooled results revealed significant association between SMAD3 rs12901499 polymorphism and both knee and hip OA (knee OA: OR 1.18, 95% CI 1.04–1.34; hip OA: OR 1.31, 95% CI 1.18–1.44). Conclusion: The current meta-analysis revealed that the G variant of SMAD3 rs12901499 polymorphism increased the risk of OA in Caucasians. Further well-designed studies with larger sample size in different ethnic populations are required to confirm these results. Keywords: SMAD3, Polymorphism, Osteoarthritis, Meta-analysis
Background Osteoarthritis (OA), a late-onset musculoskeletal disease in the elder, is featured by the gradual degradation of articular cartilage with further lesion to the synovium, subchondral bone, or the other joint tissues. The osteoarthritis could cause chronic joint pain with swelling and restricted range of motion through the pathologic process including narrowing of joint space and osteophyte formation [1–3]. It was estimated that over 15% of the population suffered from OA, and the number tends to be doubled by 2020 due to the increasing elder population [4, 5]. Though the mechanism of osteoarthritis still has not been fully clarified, * Correspondence: [email protected] † Jian-qiao Hong and Yang-xin Wang contributed equally to this work. Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, No.88 Jiefang Road, Hangzhou 310009, People’s Republic of China
a large number of risk factors have been reported, including age, sex, obesity, trauma in the joint, environmental factors, and genetic factors [3, 6, 7]. The SMAD3 (SMAD family member 3) gene, located on chromosome 15q22.33, acts a critical role in the joint homeostasis [8
Data Loading...
