Association of circulating PCSK9 concentration with cardiovascular metabolic markers and outcomes in stable coronary art
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ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
Association of circulating PCSK9 concentration with cardiovascular metabolic markers and outcomes in stable coronary artery disease patients with or without diabetes: a prospective, observational cohort study Jia Peng†, Ming‑Ming Liu†, Jing‑Lu Jin, Ye‑Xuan Cao, Yuan‑Lin Guo, Na‑Qiong Wu, Cheng‑Gang Zhu, Qian Dong, Jing Sun, Rui‑Xia Xu* and Jian‑Jun Li*
Abstract Background: Whether plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels is a predictor for cardio‑ vascular outcomes has currently been controversial. No data is currently available regarding the relation of PCSK9 to cardiovascular metabolic markers (CVMMs) and major adverse cardiovascular events (MACEs) in stable coronary artery disease (CAD) patients with diabetes or without diabetes. Methods: A total 1225 untreated patients with stable CAD were consecutively enrolled and their baseline plasma PCSK9 levels were determined by ELISA. Patients were divided into high and low PCSK9 groups according to PCSK9 median. All patients followed up for the occurrence of MACEs and received standard therapy after admission. The associations of PCSK9 with CVMMs and MACEs were evaluated. Results: PCSK9 levels were positively correlated with multiple CVMMs including total cholesterol, low-density lipo‑ protein cholesterol, non-high-density lipoprotein cholesterol and hemoglobin A1c at baseline (all p
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