Association of Eosinophilic Esophagitis and Human Immunodeficiency Virus

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ORIGINAL ARTICLE

Association of Eosinophilic Esophagitis and Human Immunodeficiency Virus Mohammad Maysara Asfari1   · Katherine Kendrick2 · Muhammad Talal Sarmini3 · Pearl Uy1 · Kenneth J. Vega1 Received: 31 March 2020 / Accepted: 14 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract Background  Eosinophilic esophagitis (EoE) is thought to be an atopic disorder causing dysphagia. HIV patients have dysphagia from both common (reflux esophagitis) and uncommon causes (idiopathic esophageal ulceration). Only a single case report about the occurrence of EoE in an HIV patient exists in literature. Aim  The aim of this study was to determine if HIV and EoE occur concurrently using a large inpatient database. Methods  Data on hospital admissions of all HIV adult patients were extracted from the 2002–2014 National Inpatient Sample. Comorbidities and outcomes of interest were defined by querying all diagnostic and procedural fields for the corresponding ICD-9 codes. Univariable and multivariable logistic regression analysis was performed to assess the association between HIV and EoE. Similarly, we assessed the relation between HIV and eosinophilic gastroenteritis (EGE). Results  The total population comprised of 101,137,145 patients, of which 231,691 (0.229%) have HIV and 5038 (0.004%) have EoE. HIV patients were younger (45.2 vs 48 years old and more likely to be male (62.2% vs 41.5%) and African American (53.9% vs 14.2%) compared to non-HIV patients (P