Association of HIV infection with clinical and laboratory characteristics of sickle cell disease
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RESEARCH ARTICLE
Open Access
Association of HIV infection with clinical and laboratory characteristics of sickle cell disease André Rolim Belisário1* , Paula F. Blatyta2, Diana Vivanco3, Claudia Di Lorenzo Oliveira4, Anna Bárbara Carneiro-Proietti1 , Ester Cerdeira Sabino5 , Cesar de Almeida-Neto2,6, Paula Loureiro7,8 , Cláudia Máximo9 , Sheila de Oliveira Garcia Mateos5,9, Miriam V. Flor-Park10 , Daniela de Oliveira Werneck Rodrigues1 , Rosimere Afonso Mota1 , Thelma T. Gonçalez11, Thomas J. Hoffmann3, Shannon Kelly11,12 , Brian Custer3,11 and for the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) International Component Brazil
Abstract Background: Sickle cell disease (SCD) is a multisystem disorder characterized by a wide spectrum of clinical manifestations and severity. Studies investigating potential effects of co-morbid human immunodeficiency virus (HIV) and SCD have produced conflicting results, and additional investigations are needed to elucidate whether the interaction between the two disease states might impact both HIV and SCD clinical outcomes. The association of HIV infection with clinical and laboratory characteristics of patients with SCD was assessed. Methods: This nested case-control study included individuals with SCD with HIV treated at six Brazilian SCD centers. Clinical and laboratory data were abstracted from medical records. HIV positive participants were compared to age, gender, center, and SCD genotype matched HIV negative participants (ratio 1:4). Individual clinical outcomes as well as a composite outcome of any SCD complication and a composite outcome of any HIV-related complication were compared between the two groups. (Continued on next page)
* Correspondence: [email protected] 1 Fundação Hemominas, Alameda Ezequiel Dias, 321, Belo Horizonte, Minas Gerais 30130-110, Brazil Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Belisário et al. BMC Infectious Diseases
(2020)
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