Associations between visceral obesity and renal impairment in health checkup participants: a retrospective cohort study
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ORIGINAL ARTICLE
Associations between visceral obesity and renal impairment in health checkup participants: a retrospective cohort study Yoshikazu Miyasato1 · Koji Oba1,2 · Shinji Yasuno3 · Yutaka Matsuyama1 · Izuru Masuda4 Received: 17 December 2019 / Accepted: 21 June 2020 © Japanese Society of Nephrology 2020
Abstract Background Obesity is a risk factor for chronic kidney disease. Although body mass index (BMI) or waist circumference is indicators of obesity, actual measurements of visceral fat area (VFA) more accurately reflect the amount of visceral fat. We aimed to determine the most sensitive obesity indicator for predicting renal impairment among VFA, BMI, waist circumference, waist-to-height ratio, and visceral-to-subcutaneous fat ratio (VSR). Methods Subjects who underwent VFA measurements during health checkups in 2012 were included. Obesity was defined using a separate baseline value for each indicator [VFA (100 cm2), BMI (25 kg/m2), waist circumference (85 cm for men and 90 cm for women), waist-to-height ratio (0.5), VSR (0.4)]. Changes in estimated glomerular filtration rate (eGFRcr) and time to new-onset proteinuria were measured. The relationships between obesity indicators and eGFRcr were evaluated using a linear mixed-effects model. The relationships between obesity indicators and new-onset proteinuria were evaluated using Poisson regression analysis. Results Analysis was performed on 2753 subjects (mean age 50.3 years). The VFA ≥ 100 cm2 group exhibited a larger annual difference in eGFRcr compared to the
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