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Anaphylaxis: case report A 57-year-old woman developed anaphylaxis following accidental occupational exposure to irbesartan. Additionally, she was also occupationally exposed to atenolol. The woman, who was working as a health care aide, was referred due to unexplained anaphylaxis. She reported that she handled atenolol and irbesartan at her client’s house earlier that day and subsequently rubbed her eyes. Within 10 minutes, she developed flushing, lip swelling and rashes on her face. She presented to the emergency room and was found to be stridorous. The woman was treated with epinephrine and unspecified antihistamines and steroids. However, she required intubation for respiratory distress. Therefore, a graded oral challenge with irbesartan was performed which resulted in visible lip angioedema, nausea, dizziness and substantial hypotension. She was given two doses of epinephrine in the office with resolution of symptoms. Subsequently, she well tolerated a graded challenge with atenolol. She was diagnosed with irbesartan allergy. Barlas A, et al. Anaphylaxis caused by trace exposure to angiotensin II blocker in a healthcare worker: A case report. Allergy, Asthma and Clinical Immunology 16 (Suppl. 803515270 1): 6 abstr. 15, 2020. Available from: URL: http://doi.org/10.1186/s13223-020-00445-x [abstract]

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Reactions 14 Nov 2020 No. 1830