Atezolizumab
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Colitis and exacerbation of sarcoidosis: case report In a retrospective cohort study of 32 patients presented at Anderson Cancer Center, USA between 2016 and 2019, a patient [age and sex not stated] was described, who developed colitis and exacerbation of sarcoidosis during treatment with atezolizumab [dosage, route and outcomes not stated; not all time to reactions onset stated]. The patient, who had a 20-year remote history of sarcoidosis (treatment naive), developed a clinically symptomatic exacerbation of sarcoidosis one month following initiation of atezolizumab along with increased hilar nodules on imaging, skin nodules, arthritis and uveitis. Biopsy of a lymph node revealed non-necrotising granulomas, and biopsy of the skin showed panniculitis. The patient also developed colitis, speculated to be an immune-related adverse event. Atezolizumab was discontinued after a total of 3 doses. The Patient was treated with prednisone and azathioprine. Pundole X, et al. Immune checkpoint inhibitor therapy in patients with preexisting sarcoidosis. Annals of the Rheumatic Diseases 79 (Suppl. 1): 1225-1226 abstr. SAT0536, 2 803516383 Jun 2020. Available from: URL: http://doi.org/10.1136/annrheumdis-2020-eular.5839 [abstract]
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Reactions 21 Nov 2020 No. 1831
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