AUGS/IUGA Scientific Meeting
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AUGS/IUGA Scientific Meeting Abstracts of Poster Presentations, IUGA 44th Annual Meeting – Nashville, TN, USA, September 24–28, 2019 Published online: 23 September 2019 # The International Urogynecological Association 2019
Poster 1 HISTOLOGICAL EVIDENCE SUPPORTS LOW BLADDER C A PA C I T Y A S A B L A D D E R - C E N T R I C D I S E A S E PHENOTYPE IN INTERSTITIAL CYSTITIS/ BLADDER PAIN SYNDROME J. Schachar1, R. J. Evans1, G. Parks2, H. Heath3, C. A. Matthews4, G. Badlani1, A. Plair1, J. Zambon5 and S. Walker3. 1Wake Forest Baptist Health, Winston-Salem, NC, 2Wake Forest Baptist Health, WinstonSalem, NC, 3Institute for Regenerative Medicine, Wake Forest Baptist Health, Winston-Salem, NC, 4Wake Forest School of, Winston Salem, NC, 5Wake Forest Baptist Health, Winston Salem, NC Objective: Accumulating evidence supports low anesthetic bladder capacity as a clinically relevant biomarker for bladder-centric interstitial cystitis/bladder pain syndrome (IC/BPS). The goal of this study was to determine if histopathological evidence from bladder biopsies taken at the time of bladder hydrodistention further supports bladder capacity (BC) as a marker to distinguish IC/BPS sub-types. Methods: Patients being evaluated for IC/BPS and who were scheduled for cystoscopy with hydrodistention (HOD) have been prospectively enrolled from a single clinic since 2014. A review of the entire IC/BPS cohort (n=380) identified a total of 41 patients with low BC (≤ 400 ml). An additional 41 consecutive patients with BC > 400mL were selected as the comparator group. The original pathology slides were prepared and reviewed by 25 different pathologists at the time of the procedure and therefore accurate comparisons could not be performed. Thus, the original slides were obtained and re-reviewed by a single pathologist (who was blinded to bladder capacity and patient information) using a standardized grading scale developed for this study. Results: Histology slides from 73 of 82 patients (34 with BC ≤ 400; 39 with BC > 400ml) were available for re-analysis. Upon re-review of the original slides, the low capacity patients were found to exhibit higher levels of acute inflammation (p=0.0299), chronic inflammation (p=0.0139), and ulceration (p=0.0155), however there was no significant difference in mast cell count between groups (p=0.4431). Individuals in the low capacity group were older (p0.05). Conclusions: The vast majority of AUGS attendee survey respondents perform minimally invasive sacral colpopexy, with similar distribution of robotic and laparoscopic cases. Concomitant surgeries of the posterior wall are commonly performed. Other than more hysteropexies performed by females there were no other identified demographic variables to predict technique variations. While this potentially suggests homogeneity of technique, results should be interpreted with caution given the low response rate. Disclosures: A. Dubinskaya: Nothing to disclose; J. P. Shepherd: Nothing to disclose.
Int Urogynecol J (2019) 30 (Suppl 1):S219–S380
Poster 28 EVA
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