Automated ASPECT scoring in acute ischemic stroke: comparison of three software tools
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DIAGNOSTIC NEURORADIOLOGY
Automated ASPECT scoring in acute ischemic stroke: comparison of three software tools Philip Hoelter 1
&
Iris Muehlen 1 & Philipp Goelitz 1 & Vanessa Beuscher 2 & Stefan Schwab 2 & Arnd Doerfler 1
Received: 10 February 2020 / Accepted: 16 April 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Various software applications offer support in the diagnosis of acute ischemic stroke (AIS), yet it remains unclear whether the performance of these tools is comparable to each other. Our study aimed to evaluate three fully automated software applications for Alberta Stroke Program Early CT (ASPECT) scoring (Syngo.via Frontier ASPECT Score Prototype V2, Brainomix e-ASPECTS® and RAPID ASPECTS) in AIS patients. Methods Retrospectively, 131 patients with large vessel occlusion (LVO) of the middle cerebral artery or the internal carotid artery, who underwent endovascular therapy (EVT), were included. Pre-interventional non-enhanced CT (NECT) datasets were assessed in random order using the automated ASPECT software and by three experienced neuroradiologists in consensus. Interclass correlation coefficient (ICC), Bland-Altman, and receiver operating characteristics (ROC) were applied for statistical analysis. Results Median ASPECTS of the expert consensus reading was 8 (7–10). Highest correlation was between the expert read and Brainomix (r = 0.871 (0.818, 0.909), p < 0.001). Correlation between expert read and Frontier V2 (r = 0.801 (0.719, 0.859), p < 0.001) and between expert read and RAPID (r = 0.777 (0.568, 0.871), p < 0.001) was high, respectively. There was a high correlation among the software tools (Frontier V2 and Brainomix: r = 0.830 (0.760, 0.880), p < 0.001; Frontier V2 and RAPID: r = 0.847 (0.693, 0.913), p < 0.001; Brainomix and RAPID: r = 0.835 (0.512, 0.923), p < 0.001). An ROC curve analysis revealed comparable accuracy between the applications and expert consensus reading (Brainomix: AUC = 0.759 (0.670– 0.848), p < 0.001; Frontier V2: AUC = 0.752 (0.660–0.843), p < 0.001; RAPID: AUC = 0.734 (0.634–0.831), p < 0.001). Conclusion Overall, there is a convincing yet developable grade of agreement between current ASPECT software evaluation tools and expert evaluation with regard to ASPECT assessment in AIS. Keywords Aspects . Software anylsis . Diagnostics . Acute ischemic stroke
Introduction Non-enhanced computed tomography (NECT) has been the most widely used imaging tool for evaluation of acute ischemic stroke (AIS) for a long time. Analysis of early ischemic changes (EICs) on NECT supports treatment decisions for PH and IM contributed equally to this work. * Philip Hoelter [email protected] 1
Department of Neuroradiology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany
2
Department of Neurology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany
endovascular therapy (EVT) and outcome prognosis in patients with acute ischemic stroke [1
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