Automated computed tomography quantification of fibrosis predicts prognosis in combined pulmonary fibrosis and emphysema
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RESEARCH
Automated computed tomography quantification of fibrosis predicts prognosis in combined pulmonary fibrosis and emphysema in a real‑world setting: a single‑centre, retrospective study Masahiro Nemoto1,2* , Yuichiro Nei3, Brian Bartholmai4, Kazuki Yoshida5, Hiroki Matsui6, Tamao Nakashita7, Shinji Motojima7, Masahiro Aoshima2 and Jay H. Ryu8
Abstract Background: Combined pulmonary fibrosis and emphysema (CPFE) is a heterogeneous clinico-radiological syndrome without a consensus definition. There are limited data on the relation between the amount of parenchymal fibrosis and prognosis. In this study, we assessed the prognostic implications of the extent of fibrosis assessed by an automated quantitative computed tomography (CT) technique and the radiological and functional change over time in patients with a broad spectrum of fibrotic interstitial lung diseases (ILDs) encountered in a real-world setting. Methods: We conducted a single-centre, retrospective study of 228 consecutive patients with CPFE, encountered from 2007 to 2015 at Kameda Medical Center, Chiba, Japan. We investigated the prognostic value of automated CT fibrosis quantification and the subsequent course of CPFE. Results: Among 228 patients with CPFE, 89 had fibrosis affecting
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