Axitinib
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Pneumatosis intestinalis and acute acalculous cholecystitis: case report A 71-year-old man developed pneumatosis intestinalis and acute acalculous cholecystitis following treatment with axitinib for metastatic renal cell carcinoma. The man, who had lung metastasis of renal cell carcinoma after partial nephrectomy, started receiving treatment with axitinib [dosage and route not stated]. Twenty-four days following the initiation of axitinib, he presented with abdominal pain. A CT scan demonstrated gas in the intestinal wall. He was diagnosed with pneumatosis intestinalis secondary to axitinib. Consequently, the man was treated with unspecified antibiotics and bowel rest. Axitinib was stopped. His condition improved. However, he developed a fever and right upper quadrant pain 16 days following the cessation of axitinib. A magnetic resonance cholangiopancreatography demonstrated gallbladder dilation without stones, confirming the diagnosis of axitinib-associated acute acalculous cholecystitis. His condition improved again with unspecified conservative treatments. Author comment: "This is the first case report of axitinibinduced [pneumatosis intestinalis] and [acute acalculous cholecystitis] (Naranjo probability score: 6), although [pneumatosis intestinalis] and [acute acalculous cholecystitis] have been reported as adverse events of other [anti-vascular endothelial growth factor] agents." Kameda T, et al. Axitinib-induced Pneumatosis Intestinalis and Acute Acalculous Cholecystitis in a Patient With Renal Cell Carcinoma. Urology 101: e7-e8, Mar 2017. Available from: URL: http://doi.org/10.1016/j.urology.2016.12.035 803443677 Japan
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Reactions 4 Jan 2020 No. 1785
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