Bacteriocins of Lactic Acid Bacteria Microbiology, Genetics and Appl
As antibacterial compounds, bacteriocins have always lived in the shadow of those medically important, efficient and often broad-spectrum low-molecular mass antimicrobials, well known even to laypeople as antibiotics. This is despite the fact that bacter
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BACTERIOCINS OF LACTIC ACID BACTERIA Microbiology, Genetics and Applications
Edited by
LUC DE VUYST and
ERICK J . V A N D A M M E Laboratory of Industrial Microbiology and Biocatalysis, University of Gent, Belgium
m
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
ISBN 978-1-4613-6146-6 DOI 10.1007/978-1-4615-2668-1
ISBN 978-l-4615-2668-l (eBook)
First edition 1994 © 1994 Springer Science+Business M e d i a N e w Y o r k Originally published by Blackie Academic & Professional in 1994 Typeset in 10/12pt Times by The Universities Press (Belfast) Ltd.
Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the U K Copyright Designs and Patents Act, 1988, this publication may not be reproduced, stored, or transmitted, in any form or by any means, without the prior permission in writing of the publishers, or in the case of reprographic reproduction only in accordance with the terms of the licences issued by the Copyright Licensing Agency in the U K , or in accordance with the terms of licences issued by the appropriate Reproduction Rights Organization outside the U K . Enquiries concerning reproduction outside the terms stated here should be sent to the publishers at the Glasgow address printed on this page. The publisher makes no representation, express or implied, with regard to the accuracy of the information contained in this book and cannot accept any legal responsibility or liability for any errors or omissions that may be made. A catalogue record for this book is available from the British Library
Library of Congress Cataloging-in-Publication Data Bacteriocins of lactic acid bacteria : microbiology, genetics and applications / edited by Luc De Vuyst and Erick J. Vandamme. p. cm. Includes bibliographical references and index. 1. Bacteriocins. 2. Lactic acid bacteria. I. Vuyst, Luc De. II. Vandamme, Erick J., 1943- . I l l Series. QR92.B3B353 1994 615'.32995-dc20 ^ - ^ Printed on acid-free text paper, manufactured in accordance with ^ ANSI/NISO Z39.48-1992 (Permanence of Paper).
93-1320 CIP
PREFACE As antibacterial compounds, bacteriocins have always lived in the shadow of those medically important, efficient and often broad-spectrum low-molecularmass antimicrobials, well known even to laypeople as antibiotics. This is despite the fact that bacteriocins were discovered as early as 1928, a year before the penicillin saga started. Bacteriocins are antimicrobial proteins or oligopeptides, displaying a much narrower activity spectrum than antibiotics; they are mainly active against bacterial strains taxonomically closely related to the producer strain, which is usually immune to its own bacteriocin. They form a heterogenous group with regard to the taxonomy of the producing bacterial strains, mode of action, inhibitory spectrum and protein structure and composition. Best known are the colicins and microcins produced by Enterobacteriaceae. Many other Gram-negative as well as Gram-positive bacteria have now been found to produce bacter
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