Baseline Demographics and Clinical Characteristics Among 3471 US Patients Hospitalized with COVID-19 and Pulmonary Invol
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ORIGINAL RESEARCH
Baseline Demographics and Clinical Characteristics Among 3471 US Patients Hospitalized with COVID-19 and Pulmonary Involvement: A Retrospective Study Jennie H. Best . Shalini V. Mohan . Amanda M. Kong . Krish Patel . John M. Pagel . Boris Ivanov . Otis W. Brawley . Krutika Jariwala-Parikh . James L. Zazzali . John Pauk
Received: August 17, 2020 / Accepted: September 16, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Coronavirus disease 2019 (COVID-19) can present as a range of symptoms, from mild to critical; lower pulmonary involvement, including pneumonia, is often associated with severe and critical cases. Understanding the baseline characteristics of patients hospitalized with COVID-19 illness is essential for effectively targeting clinical care and allocating resources. This study aimed to describe baseline demographics and clinical
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12325020-01510-y) contains supplementary material, which is available to authorized users. J. H. Best (&) S. V. Mohan J. L. Zazzali Genentech, Inc., South San Francisco, CA, USA e-mail: [email protected] A. M. Kong B. Ivanov K. Jariwala-Parikh IBM Watson Health, Cambridge, MA, USA K. Patel J. M. Pagel Swedish Cancer Institute, Seattle, WA, USA O. W. Brawley Johns Hopkins Medicine, Baltimore, MD, USA J. Pauk Swedish Medical Center, Seattle, WA, USA
characteristics of US patients hospitalized with COVID-19 and pulmonary involvement. Methods: US patients with COVID-19 and pulmonary involvement during an inpatient admission from December 1, 2019, to May 20, 2020, were identified using the IBM ExplorysÒ electronic health records database. Baseline (up to 12 months prior to first COVID-19 hospitalization) demographics and clinical characteristics and preadmission (14 days to 1 day prior to admission) pulmonary diagnoses were assessed. Patients were stratified by sex, age, race, and geographic region. Results: Overall, 3471 US patients hospitalized with COVID-19 and pulmonary involvement were included. The mean (SD) age was 63.5 (16.3) years; 51.2% of patients were female, 55.0% African American, 81.6% from the South, and 16.8% from the Midwest. The most common comorbidities included hypertension (27.7%), diabetes (17.3%), hyperlipidemia (16.3%), and obesity (9.7%). Cough (27.3%) and dyspnea (15.2%) were the most common preadmission pulmonary symptoms. African American patients were younger (mean [SD], 62.5 [15.4] vs. 67.8 [6.2]) with higher mean (SD) body mass index (33.66 [9.46] vs. 30.42 [7.86]) and prevalence of diabetes (19.8% vs. 16.7%) and lower prevalence of chronic obstructive pulmonary disease (5.6% vs. 8.2%) and smoking/tobacco use (28.1% vs. 37.2%) than White patients. Conclusions: Among US patients primarily from the South and Midwest hospitalized with
Adv Ther
COVID-19 and pulmonary involvement, the most common comorbidities were hypertension, diabetes, hyperlipidemia, and obesity. Differences observed between African American and White pati
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