Behavioral Neurobiology of the Endocannabinoid System
The endocannabinoid signalling system is one of the key modulators of central nervous function. This volume provides timely and in-depth coverage of the roles of the endocannabinoid signalling system in the neurobiology of behavior. It is essential readin
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Behavioral Neurobiology of the Endocannabinoid System David Kendall Stephen Alexander Editors
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Current Topics in Behavioral Neurosciences Series Editors: Mark Geyer, La Jolla, CA, USA Bart Ellenbroek, Hamburg, Germany Charles Marsden, Nottingham, UK
About this series Current Topics in Behavioral Neurosciences provides critical and comprehensive discussions of the most significant areas of behavioral neuroscience research, written by leading international authorities. Each volume offers an informative and contemporary account of its subject, making it an unrivalled reference source. Titles in this series are available in both print and electronic formats. With the development of new methodologies for brain imaging, genetic and genomic analyses, molecular engineering of mutant animals, novel routes for drug delivery, and sophisticated cross-species behavioral assessments, it is now possible to study behavior relevant to psychiatric and neurological diseases and disorders on the physiological level. The Behavioral Neurosciences series focuses on ‘‘translational medicine’’ and cutting-edge technologies. Preclinical and clinical trials for the development of new diagnostics and therapeutics as well as prevention efforts are covered whenever possible.
Dave Kendall
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Stephen Alexander
Editors
Behavioral Neurobiology of the Endocannabinoid System
Editors Prof. David A. Kendall Dr. Stephen Alexander University of Nottingham Queen’s Medical Centre School of Biomedical Sciences Nottingham, NG7 2UH United Kingdom [email protected] [email protected]
ISSN 1866-3370 e-ISSN 1866-3389 ISBN 978-3-540-88954-0 e-ISBN 978-3-540-88955-7 DOI: 10.1007/978-3-540-88955-7 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2009928098 # Springer-Verlag Berlin Heidelberg 2009 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover illustration: Artistic representation of oscillatory synchrony and timing of neurons in networks by Gyorgy Buzsaki Cover design: WMXDesign GmbH, Heidelberg, Germany Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
It is abundantly clear that the endocannabinoid signalling system is ubiquitously ex
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