Bicarbonate
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Iatrogenic metabolic alkalosis: case report A 76-year-old woman developed iatrogenic metabolic alkalosis during treatment with bicarbonate for urinary alkalinisation. The woman, who had diffuse large B-cell lymphoma with central nervous system (CNS) involvement, was admitted for the first cycle of high dose methotrexate therapy (HDMTX). Subsequently, she started receiving bicarbonate infusion for urinary alkalinisation. Her baseline bicarbonate (HCO3) level was 28 mEq/L. After 48 hours, she was found to have elevated methotrexate level. Hence, the urinary alkalinisation protocol was continued until
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