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Various toxicities: 3 case reports In a study of 30 patients, 3 patients [ages and sexes not stated] were described, who developed toxico-allergic reaction, oedema of the periorbital tissues, hyperaemia of the periorbital tissues, second-degree conjunctival hyperaemia, punctate keratopathy or bradycardia during treatment with bimatoprost/timolol [Bimoptic Plus] for primary open-angle glaucoma (POAG) [times to reactions onsets and outcomes not stated]. The patients, who had POAG, started receiving intraocular drops of bimatoprost/timolol (0.03%/0.5%) instilled once a day in the morning. Of the 3 patients, two patients developed toxicoallergic reactions in the form of oedema of the periorbital tissues, hyperaemia of the periorbital tissues, second-degree conjunctival hyperaemia and punctate keratopathy secondary to treatment with bimatoprost/timolol. Thus, treatment with bimatoprost/timolol was withdrawn on day 3 in 1 patient and on day 5 in the other patient. The third patient from group 1, who was receiving bimatoprost/timolol as the initial therapy for POAG, developed bradycardia with the pulse less than 56 beats/min. Thus, this patient’s treatment with bimatoprost/timolol was discontinued in 1 month. Kosakyan SM, et al. Effectiveness and safety of drug combination therapy in patients with advanced primary open-angle glaucoma. Vestnik Oftalmologii 136: 96-102, No. 5, 803522184 2020. Available from: URL: http://doi.org/10.17116/oftalma202013605196 [Russian; summarised from a translation]

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Reactions 19 Dec 2020 No. 1835