Biography: Carel le Roux
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BIOGRAPHY
Biography: Carel le Roux Carel W. le Roux 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Professor Carel le Roux was awarded the Anglo-American Open scholarship which enabled him to be the first in his family to attend University. He graduated from medical school in Pretoria, South Africa in 1996. While completing his medical degree, he represented South Africa at the Track and Field World Championships in 1995, Commonwealth Games in 1994 and won the All African Championships in 1993. After graduating, he moved to the UK initially with the intention to return to South Africa after a year. Those plans changed after he met Jenny and decided to complete his specialist training in metabolic medicine at St Bartholomew’s Hospitals and the Hammersmith Hospitals in London. He was awarded a Wellcome Clinical Research Fellowship and obtained his PhD from Imperial College London. During his PhD, he became interested in bariatric surgery as a method to maintain long-term weight loss. Working in Sir Steve Bloom’s lab, he was lucky enough to have access to a wide array of gut hormone assays. He fortuitously was given access to patients after Roux-en-Y gastric bypass surgery and measured their post prandial gut hormone responses. He invited three or four
* Carel W. le Roux [email protected] 1
University College Dublin, Dublin, Ireland
patients at a time to have the 3-h mixed meal tests, and it was while he was performing venepuncture that he eavesdropped on their conversations. Listening to the patients share with each other, all the changes they experienced after surgery enabled him to formulate research questions which served him for the next 20 years of his career. He was part of the first wave of clinician scientists to explore how the gut was able to increase signalling to the brain after bariatric surgery. This opened new vistas on the possibilities of bariatric surgery as biological treatments for the biological disease of obesity. A National Institute of Health Research Clinician Scientist award enabled him to take up a faculty position at Imperial and established the first fully integrated multidisciplinary obesity service in the UK. Many of the members of the clinical team also completed PhDs investigating gut brain signalling after bariatric surgery, and they have become his colleagues and friends. In 2012, he was awarded the President of Ireland Young Researcher award and moved to University College Dublin to become the Chair in Experimental Pathology. He is now the Director of the Metabolic Medicine Group where his translational research program focusses on how the gut talks to the brain. His clinical and basic research is supported by an Irish Research Council Laureate Award as well as a Health Research Board and National Institute of Health USIreland Partnership Award. This enables him to explore the mechanisms of bariatric surgery together with close collaborators to allow better clinical care for patients. His group was at the forefront when the role of gut hormones after
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