Biological Networks and Pathway Analysis
In this volume, expert practitioners present a compilation of methods of functional data analysis (often referred to as “systems biology”) and its applications in drug discovery, medicine, and basic disease research. It covers such important i
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Tatiana V. Tatarinova Yuri Nikolsky Editors
Biological Networks and Pathway Analysis
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Biological Networks and Pathway Analysis
Edited by
Tatiana V. Tatarinova Keck School of Medicine University of Southern California Los Angeles, CA, USA
Yuri Nikolsky Prosapia Genetics Solana Beach, CA, USA
Editors Tatiana V. Tatarinova Keck School of Medicine University of Southern California Los Angeles, CA, USA
Yuri Nikolsky Prosapia Genetics Solana Beach, CA, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7025-4 ISBN 978-1-4939-7027-8 (eBook) DOI 10.1007/978-1-4939-7027-8 Library of Congress Control Number: 2017937364 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Google queries for systems biology and pathway analysis fetch over 9 million and 14 million entries, respectively. These numbers speak volumes about the utility and popularity of systems data analysis in modern bioscience. These days, any gene expression or SNPanalyzing manuscript would feature a chapter on pathways, ontology enrichment, and/or biological networks. The application of systems biology approaches now spreads widely from basic research and preclinical drug discovery to translational research and personalized healthcare. Systems biology “focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integrat
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